ARKOPHARMA COOPERATION ARKOPHARMA Laboratories is VISION’s main strategic Pharmaceutical partner, and one of the largest pharmaceutical concerns in Europe. VISION has built, in cooperation with ARKOPHARMA, its own manufacturing plant in Ireland, Nutripharma, Good Manufacturing Practices (GMP) certified. It's a privilege for Arkopharma to cooperate with Vision for more than 15 years A strong, stable pharmaceutical partnership ENJOY NT® development Enjoy NT®: The highest standards in product development, based on - clinical studies, deep bibliographic reviews with Arkopharma’s scientific specialists and doctors; - market analysis and opportunities studies to find real innovations - high-level sourcing and raw material quality analysis For Arkopharma Laboratories, EnjoyNT is a real, great, potential business opportunity We thank, and congratulate all Distributors for the EnjoyNT launch A high added-value & high potential product BENEFITS THE BEST INGREDIENTS FOR JOINT’S SUPPORT Glucosamine Origin : Marine origin : shrimps and prawn “cuticle” Quality : tested and approved by Arkopharma (quality, quantity) by chromatography History : •A worldwide increase in prescriptions for joints & arthritis over the last 10 years, and a 2 billions $ market worldwide. •Naturally produced by our organism to maintain cartilage and joints healthy. •In the 60’s, glucosamine was directly injected in veins for people with arthritis. A worldwide use, a natural marine origin THE BEST INGREDIENTS FOR JOINTS SUPPORT Glucosamine No side-effects (lesquesnes index) Results of single glucosamine : • decrease in pain & joints dysfunctions in 6 months: 163% decrease vs placebo in the Lesquesnes score • after 12 weeks : 88% improvement vs 17% in the placebo group Pain & knee dysfunciton Mechanism of action : cartilage & synovial liquid synthesis hydrocolloid properties cartilage resistance -1.9 -163% -3.1 placebo Gluccsamine hcl Decrease in Pain & knee dysfunction after 6 months HERRERO-BEAUMONT, 2007 THE NATURAL CARTILAGE BOOSTER THE BEST INGREDIENTS FOR JOINTS SUPPORT Chondroïtine Origin : Marine origin : edible sharks (non protected species) Quality : chondroïtine sulfate 100% shark origin History : •Used since the 60’s in veterinarian remedies! (intramuscular injections) •Was developed since 90’s, following the clinical studies about its synergy with glucosamine A worldwide use, a natural marine origin THE BEST INGREDIENTS FOR JOINTS SUPPORT Chondroïtine Mechanism of action : cartilage synthesis, inhibition of its destruction, anti-inflammatory protection of synovial liquid Results of single chondroïtine : More than 10 controlled clinical studies demonstrate a good efficacy of chondroitin in reducing joint pain with a persistence of efficacy over time. No side-effects THE NATURAL PROTECTOR (synovial liquid, cartilage) THE BEST INGREDIENTS FOR JOINTS SUPPORT The very famous “GAIT” study demonstrated the clinical efficacy of the association of glucosamine hydrochloride and chondroitine sulfate. GLUCOSAMINE + CHONDROÏTINE Human Chondrocyte producing : CARTILAGE MATRIX collagen Chondro+gluco ! Chondroïtine alone placebo Glucosamine alone hyaluronic acid chondrotin sulfate + glucosamine The best synergy ! *feb. 2006; new england journal of medicine, GAIT = Glucosamide/ Chondroïtine Arthritis Intervention Trial) THE BEST INGREDIENTS FOR JOINTS SUPPORT MSM Origin : Methyl Sulfonyl Methane, is a sulfurated compound which is present in some food (trace element). Quality : minimal size = 250 microns (µm) History : •2 american doctors (Dr Jacob & Dr Lawrence, UCL), published a book on the miracles of MSM showing it was as efficient as ibuprofen for its anti-inflammatory functions to relieve painful joints, but without side effects. A miraculous ingredient ! THE BEST INGREDIENTS FOR JOINTS SUPPORT MSM Mechanism of action : anti-inflammatory, protection against free radicals, antioxidant. Results : single MSM: results vs placebo: performing activities of daily living when compared to placebo, and 80% improvement after 6 weeks compared to 20% in the placebo-group. in combination with glucosamine and chondroïtine : demonstrated synergic effect over 12 weeks No side-effects Results on quality of life, in synergy! THE BEST INGREDIENTS FOR JOINTS SUPPORT BAMBOOSIL QUALITY extreme richness in silicon (as silica SiO2). REMINERALISING PROPERTIES. PROPERTIES silica is involved in the synthesis of collagen and proteoglycans, the main protein of connective tissue, and in bone formation NEED FOR SILICA! bioavailability of silica in foods is low and decreases with age RESULTS •Improving the resistance of connective tissues; •Remineralization •Increase the body's defenses. REMINERALIZING ACTION THE BEST SYNERGY ! Glucosamine & Chondroïtine PROTECTION of CARTILAGE & SYNOVIAL LIQUID ANTIINFLAMMATORY MSM Bamboosil TRIPLE ACTION ON JOINTS MINERALIZATION TO RELIEVE JOINT PAIN Just one cap a day, For long term treatments, From 3 to 6 months and more. Per capsule Daily recommendations (1 caps a day) Glucosamine hydrochloride 500 mg Chondroitin sulfate sodium 10 mg Methylsulfonylmethane 10 mg Bamboosil powder (Bambusa arundinacea) 10 mg Walk tall, walk free, and look the world right in the eyes !