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DNAk = HSP70
Anfinsen Cage
1-2) SRP binds leader peptide (pausing translation), which
will take it to the proper location
3) Once in place SRP falls off and the ribosome
continues to translate protein
4) A peptidase cleaves the leader peptide and then BIP
(an HSP70 like protein) binds to facilitate proper folding.
5) Dissociation of complex
“Leader peptide”
Nobel Prize
2004
Cancer treatment
Targeting the
proteasome
Ubiquitin tagging
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