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…is just a pest
Dorsal-Ventral Cell Types
Dorsoventral Axis Specification
• Gurken expressed in perinuclear region
activates cascade that respecifies follicle
cells to become
dorsal
Grk-Torpedo Signal
Dorsalizes Follicle Cells
Dorsalization results from inhibition of
pipe synthesis
Ventral Follicle Cells
Without grk signal, pipe is synthesized
and cooperates with an as yet
unidentified substrate
Dorsoventral Polarity is
Established by a Gradient of
Nuclear-Localized Dorsal Protein
Wild-type
Dorsalized mutant
Ventralized mutant
Dorsoventral Cell Fates
Gradient of dorsal activate/represses
txn of numerous genes that ultimately
pattern the D-V axis.
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