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Non-inferiority Margin
ONTARGET Non-inferiority Comparison
CV Death / MI / Stroke
(HOPE Composite)
(P=0.0008)
1,210 (14.1%) vs. 1,190 (13.9%) 0.99 (0.91-1.07)
Telmisartan better
0.8
0.9
Ramipril better
1.0
1.1
RR (95% CI)
Adapted from The ONTARGET Investigators. N Engl J Med 2008;358:1547-59.
1.2
ONTARGET Discontinuation Rates
P<0.001
P=0.02
29.3
24.5
23
Adapted from ONTARGET Investigators.N Engl J Med 2008;358(15):1547-59.
Priorities for Vascular and Renal Protection
Clinical Strategy
Target Population
Step 1: Initiate vascular protection
All people with diabetes
Step 2: Treat elevated BP
All people with diabetes whose BP
remains ≥130/80 mm Hg after applying
vascular protective measures
Step 3: Initiate renal protection
All people with diabetes who have
proteinuria after applying vascular
measures and after achieving BP
<130/80 mm Hg
Adapted from Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Canadian
Journal of Diabetes Sept 2008;32:suppl 1.
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