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Pharmacoepidemiological Research on Outcomes of Therapeutics by a European ConsorTium
Tornado-like diagrams of the SBRAM in the Wave 1 Telithromycin Case Study
Tornado-diagram showing the results of benefit risk analyses of
Ketek in the indication CAP
Ketek
inferior
Ketek
Ketek
non-inferior
superior
Cure
W3
SAE
W3
Hepatic events
W3
Syncope
W2
Cardiac events
W2
Visual events
W1
TEAE
W1
Ketek score
+1 (in favour of ketek)
0 (neither)
-1 (in favour of comparator)
Tornado-diagram CAP
1
Pharmacoepidemiological Research on Outcomes of Therapeutics by a European ConsorTium
Tornado-diagram showing the results of benefit risk analyses of
Ketek in the indication ABS
Ketek
inferior
Ketek
Ketek
non-inferior
superior
Cure
W3
SAE
W3
Hepatic events
W3
Syncope
W2
Cardiac events
W2
Visual events
W1
TEAE
W1
Ketek score
+1 (in favour of ketek)
0 (neither)
-1 (in favour of comparator)
Tornado-diagram ABS
2
Pharmacoepidemiological Research on Outcomes of Therapeutics by a European ConsorTium
Tornado-diagram showing the results of benefit risk analyses of
Ketek in the indication AECB
Ketek
inferior
Ketek
Ketek
non-inferior
superior
Cure
W3
SAE
W3
Hepatic events
W3
Syncope
W2
Cardiac events
W2
PERSp (vs. Axithromycin)
W2
PERSp (vs. Cefuroxime)
W2
Visual events
W1
TEAE
W1
Ketek score
+1 (in favour of ketek)
0 (neither)
-1 (in favour of comparator)
Tornado-diagram AECB
3
Pharmacoepidemiological Research on Outcomes of Therapeutics by a European ConsorTium
Tornado-diagram showing the results of benefit risk analyses of
Ketek in the indication TP
Ketek
inferior
Ketek
Ketek
non-inferior
superior
Cure
W3
SAE
W3
Hepatic events
W3
Syncope
W2
Cardiac events
W2
Visual events
W1
TEAE
W1
Ketek score
+1 (in favour of ketek)
0 (neither)
-1 (in favour of comparator)
Tornado-diagram TP
4
Pharmacoepidemiological Research on Outcomes of Therapeutics by a European ConsorTium
Tornado-diagram showing the results of benefit risk analyses on
safety parameters for Ketek in indication CAP, ABS and AECB
combined
Ketek
inferior
SAE
Hepatic events
Ketek
Ketek
non-inferior
superior
W3
W3
Syncope
W2
Cardiac events
W2
Visual events
W1
TEAE
W1
Ketek score
+1 (in favour of ketek)
0 (neither)
-1 (in favour of comparator)
Tornado-diagram combined
5
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